Efficient Solid-Phase Synthesis of 3-Substituted-5-Oxo-5H-Thiazolo[2,3-b]-Quinazoline-8-Carboxamides under Mild Conditions with Two Diversity Positions
نویسندگان
چکیده
منابع مشابه
Parallel synthesis of 2-substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides.
A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1-12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic a...
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single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
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There is need to develop simple, efficient & economically viable chemical pathways to synthesise biologically active & commercially important heterocyclic Bis(indolyl) methanes1.The indole ring is an important constituent of many natural products, pharmaceuticals & other compounds of commercial importantance2. The literature survey shows that Bis(indolyl) methanes are know...
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ژورنال
عنوان ژورنال: Journal of Combinatorial Chemistry
سال: 2007
ISSN: 1520-4766,1520-4774
DOI: 10.1021/cc700122a